The Meeting the Ohio River region of the Middle Mississippi River Valley has a variety of hotels and motels that are located throughout the region.
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Americas Best Value Inn
128 E. Walnut Street
Murphysboro, IL
618- 687-2244
The hometown pride and commitment by Americas Best Value Inn owners provide every guest with exceptional comfort, quality, and service at the most affordable rates. One visit and you will know why we are Americas Best Value Inn North America.
Americas Best Value
220 S. Interstate Drive
Sikeston, MO
573-471-9700
This Americas Best Value Inn is an all-suite property with two-room suites or three-room suites. Free Wi-fi available in all rooms and hard-wired connection available public areas. Free hot continental breakfast available. There is also a game room, Victorian reading room, exercise room and a guest laundry on the premises.
Best Western Saluki Inn
801 N. Giant City Road
Carbondale, IL
618-351-6611
Whether visiting for business or for leisure, the Best Western Saluki Inn offers everything travelers need to rest and relax while on the road, including thoughtful touches in well-appointed rooms for a more comfortable stay, like cable or satellite television, a refrigerator, microwave, desk/work area and high-speed Internet access.
Budget Inn
221 S. Kingshighway Street
Perryville, MO
573-547-4516
Budget Inn is economy motel chain that offers the best room rates, basic amenities, and basic rooms at affordable room rates.
Budget Inn
1448 N. Kingshighway Street
Cape Girardeau, MO
573-334-2828
Budget Inn is economy motel chain that offers the best room rates, basic amenities, and basic rooms at affordable room rates.
Candlewood Suites
485 S. Mt. Auburn Road
Cape Girardeau, MO
573-334-6868
The spacious suites of Candlewood Suites in Cape Girardeau offer travelers room to work, relax, and offers convenient access to restaurants, shopping and the West Park business district. Located just off I-55, travelers love such amenities as a full kitchen, free Wi-fi access, business center, indoor pool, and outdoor hot tub.
Comfort Inn
1517 S. Perryville Blvd.
Perryville, MO
573-547-1727
Guests will enjoy many amenities, including free local calls, free weekday newspaper and free coffee in the lobby. There is a seasonal outdoor pool and hot tub. In addition to standard amenities, all spacious guest rooms include refrigerators, coffee makers, free high-speed Internet access in all rooms and cable television with HBO.
Comfort Inn & Suites
109 Matthews Lane
Sikeston, MO
573-472-0197
This hotel offers amenities and features like free wireless high-speed Internet access in all rooms, free local calls, and complimentary hot breakfast. All guest rooms come equipped with refrigerators, microwaves, coffee makers, curved shower rods, flat-screen televisions, voice mail, hair dryers, irons, ironing boards and cable television.
Days Inn
1500 Liberty Street
Perryville, MO
573-547-1091
Days Inn by Wyndham Perryville offers inviting rooms and free Wi-fi, along with free daily breakfast to start the morning right at this Perryville hotel.
Eagle Inn Hotel
2811 E. Marshall Street
Charleston, MO
573-683-3900
The Eagle Inn Hotel offers its guests exceptional, personalized service at this ideally located right off Interstate 57, the Eagle Inn Hotel is perfect for business and leisure travelers. This hotel offers using a local gym, free Danishes and coffee in the morning, free wireless high-speed Internet access, free local calls, copy and fax services.
Pear Tree Inn
103 Cape West Parkway
Cape Girardeau, MO
573-651-3000
Relax in a comfortable guest room featuring a clean and fresh Pear Tree Inn. Accessible rooms are designed with generous door and furniture clearances for easy movement. Stay connected with free high-speed internet access. Maintain your exercise routine in our fitness center. Start your day right with a Hampton free hot breakfast.
