Hotels & Motels in the Meeting the Ohio River Region

The Meeting the Ohio River region of the Middle Mississippi River Valley has a variety of hotels and motels that are located throughout the region.

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Hampton Inn
2175 N. Reed Station Road
Carbondale, IL
618- 549-6900

Relax in a comfortable guest room featuring a clean and fresh Hampton beds®. Accessible rooms are designed with generous door and furniture clearances for easy movement. Stay connected with free high-speed internet access. Maintain your exercise routine in our fitness center. Start your day right with a Hampton free hot breakfast.

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Heritage Motel
1209 W. Main Street
Carbondale, IL
618-457-4142

The legendary Heritage Motel offers clean and quiet rooms at reasonable rates. Rooms at the Heritage are equipped with a fridge, microwave, free Wi-fi internet, and 75 channels of cable TV in every room, as well as an on-site laundry room. Deluxe rooms with kitchenettes and apartment suites are also available.

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Holiday Inn Express
3253 William Street
Cape Girardeau, MO
573-334-4491

We know it's the extra perks that make your stay unforgettable. We provide an indoor pool and fitness center to help you relax and unwind. Be sure to stop by our breakfast bar each morning, too, for biscuits, eggs, fruit and our signature cinnamon rolls. We look forward to your next visit!

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Holiday Inn
2300 Reed Station Parkway
Carbondale, IL
618- 549-2600

At the award-winning Holiday Inn Hotel & Conference Center, our hotel staff welcomes you to the "Capital of Southern Illinois" and home to Southern Illinois University Carbondale and assures your comfort is a top priority.

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Motel 6
110 S. Interstate Drive
Sikeston, MO
573-471-7400

This Motel 6 has been fully renovated. It offers large rooms with free high speed wireless internet access and a coin laundry facility. It also has a large area for parking semi-trucks and buses.

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Quality Inn
1415 E. Main Street
Carbondale, IL
618-549-4244

Guests of this motel will enjoy free continental breakfast with hot items, free wired and wireless high-speed internet access, free local calls and free unlimited long distance calls within the United States, free newspaper, and an indoor heated pool and fitness center.

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Quality Inn
102 Drake Street
Charleston, MO
573-683-4200

Located in historic Charleston, Missouri, this Quality Inn offers a free hot breakfast, free high-speed Internet access in all rooms, lobby and breakfast area, free weekday newspaper, free local calls. There is also a seasonal outdoor pool free access to a local health club. This is a pet-friendly motel.

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Super 8
1119 Vincent Drive
Perryville, MO
573-768-8166

This Super 8 motel offers free Wi-fi Internet access, a fitness room, a heated indoor pool and spa. All hotel rooms come with microwaves and refrigerators. Kids 17 and under stay free with an adult. Finish your stay with a free SuperStart continental breakfast, including hot items.

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Super 8
1180 E. Main Street
Carbondale, IL
618-503-0663

Rely on motel hotel to provide value when you stop in from the road. Our comfortable, non-smoking rooms and suites are equipped with free Wi-fi Internet access, microwaves, and refrigerators. Handicapped-accessible accommodations are available. In the morning, enjoy free SuperStart continental breakfast. We offer free parking for your truck, bus or RV.

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Super 8
2609 E. Malone Avenue
Sikeston, MO
573-471-7944

Use the free Wi-Fi Internet or log on to high-speed Internet in our business center. Comfortable rooms help you get the rest you need, and free SuperStart continental breakfast awaits you each morning. Large-vehicle parking spaces with outdoor electrical outlets for truck, bus, or RVs. Handicapped-accessible and non-smoking rooms are available.

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Explore the Meeting the Ohio River Region